Awarded Projects Range from Opioid Addiction to Maternal Obesity

A modified hub-and-spoke model to improve access to medication for opioid use disorder

Co-principal investigators

Funder

VA Pain/Opioid CORE’s Rapid Start Funding

opioids.

The study will evaluate whether delivery of medication to veterans diagnosed with opioid use disorder improves after the implementation of a “hub-and-spoke” program. Such a program is an emerging way to treat people with opioid use disorder and includes a central “hub” of addiction medicine experts who can initiate medication assisted treatment (MAT) for patients, consult on challenging cases, and provide the necessary training to spoke providers so they can prescribe MAT. “Spokes” are healthcare locations (like primary care offices or emergency departments) that connect patients to the hub doctors and help manage and support these patients once they’ve stabilized on MAT.

Effect of complex mixtures on oxidative stress and cognition in children

Principal investigator

Co-investigators

Hailey Banack, PhD, EEH research assistant professor, James Olson, PhD, UB Distinguished Professor, Guan Yu, PhD, assistant professor, Department of Biostatistics

Funder

National Institute of Environmental Health Sciences/NIH

children sitting together and reading.

From a very young age, children are exposed to many different chemicals (from metals to air pollutants), which they experience as mixtures. This new study will examine the extent to which chemical mixtures in early- to middle-childhood affect oxidative stress, a molecular process thought to underlie the development of chronic diseases, as well as cognitive functions that underlie children’s learning and social interactions. The project will also examine the extent to which antioxidants can buffer the effects of metal mixtures on the study outcomes. The project is based in the Salud Ambiental Montevideo environmental cohort of school children in Uruguay, which Kordas co-leads with colleagues from the Catholic University of Uruguay

Evaluating the LRT method for post-marketing surveillance for drug safety: Comparison and connections with the pattern discovery framework

Principal Investigator

Funder

United States Food and Drug Administration

prescription bottles.

Many medical products are approved that were tested in a relatively small number of patients compared to the population in which they will be used. Once they’re in use in a greater number of people, they have to be continuously monitored for possible adverse reactions. This “pharmacovigilance” is vital for public health. Because no gold standard of identifying these adverse effects exists, this project will promote the use of strong scientific methods and create new ones, ultimately sharpening and facilitating accurate monitoring of adverse events.

Project: Improving function after peripheral nerve injury

Co-principal Investigator

Funder

SUNY Research Seed Grant Program

athlete in pain.

Injuries to peripheral nerves (which send messages from the spinal cord to the rest of the body) disproportionately afflict healthy young people, with large proportions of sufferers demonstrating persistent weakness. This collaborative project, which also involves researchers in the departments of Chemical and Biological Engineering, and Physiology and Biophysics, will investigate whether a gene essential to maintaining embryonic stem cells—NANOG—improves muscle re-innervation and function following an experimental nerve injury.

Protective effects of dietary pulse flours on transgenerational influence of maternal obesity

Principal investigator

Funder

USDA Agricultural Research Service

open sacks of grains, beans, rice.

The project will explore the influence of mothers eating dietary pulses (dry beans, peas, lentils) during pregnancy in protecting against the impact across generations of obesity, potentially through the change of the intestinal microbiome—the microbes that live in the intestines—in mothers and offspring.