While African American women have lower rates of breast cancer, their survival from breast cancer is poorer than for European American women. This study will examine differences in DNA methylation of breast tumors for these two groups to better understand the mechanism of this difference in tumor aggressiveness.
Title: DNA Methylation: A Mechanism for Aggressive Breast Cancer in African-American Women
Principal Investigator: Christine Ambrosone, PhD
Site Principal Investigator: Jo L. Freudenheim, PhD
Funding Agency: Health Research, Inc.
Period: 04/01/10 - 01/31/14
Abstract: The study will examine samples of breast tissue from healthy women for determinations of genome wide methylation and for elucidation of difference in DNA methylation by race. Jo Freudenheim, PhD, will participate in the study design, data analyses and interpretation, and publications.