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School of Public Health and Health Professions
University at Buffalo (UB)
School of Public Health and Health Professions
Department of Epidemiology and Environmental Health
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DNA Methylation: A Mechanism for Aggressive Breast Cancer in African-American Women

While African American women have lower rates of breast cancer, their survival from breast cancer is poorer than for European American women. This study will examine differences in DNA methylation of breast tumors for these two groups to better understand the mechanism of this difference in tumor aggressiveness.

Title: DNA Methylation: A Mechanism for Aggressive Breast Cancer in African-American Women

Principal Investigator: Christine Ambrosone, PhD

Site Principal Investigator: Jo L. Freudenheim, PhD

Funding Agency: Health Research, Inc.

Period: 04/01/10 - 01/31/14

Abstract: The study will examine samples of breast tissue from healthy women for determinations of genome wide methylation and for elucidation of difference in DNA methylation by race. Jo Freudenheim, PhD, will participate in the study design, data analyses and interpretation, and publications.

Division of Environmental Health Sciences

The multidisciplinary Division of Environmental Health Sciences brings together students and faculty from across UB to integrate perspectives from a wide range of research areas.

Researcher Spotlight

ean Wactawski-Wende, PhD, principal investigator of UB’s Women’s Health Initiative (WHI) Center, discusses the significance of the WHI, one of the longest and most comprehensive studies ever done on postmenopausal women.

Jean Wactawski-Wende, PhD, principal investigator of UB’s Women’s Health Initiative (WHI) Center, discusses the significance of the WHI, one of the longest and most comprehensive studies ever done on postmenopausal women.