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University at Buffalo (UB)
School of Public Health and Health Professions
Department of Epidemiology and Environmental Health
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Arsenic Biomethylation and Toxicity Regulation

This study will characterize and compare the kinetic parameters for arsenic biomethylation by N6AMT1 and AS3MT.

Arsenic periodic table element.

Title: Human N6AMT1 and Its Regulation of Arsenic Biomethylation and Toxicity

Principal Investigator: Xuefeng Ren, MD, PhD

Funding Agency: National Institute of Environmental Health Sciences (NIEHS)

Period: 07/24/13 - 06/30/16

Abstract: The primary objective of this study is to characterize and compare the kinetic parameters for arsenic biomethylation by N6AMT1 and AS3MT and investigate their interactive effects on arsenic metabolism and the resulting toxicological responses to arsenic.

Division of Environmental Health Sciences

The multidisciplinary Division of Environmental Health Sciences brings together students and faculty from across UB to integrate perspectives from a wide range of research areas.

Researcher Spotlight

ean Wactawski-Wende, PhD, principal investigator of UB’s Women’s Health Initiative (WHI) Center, discusses the significance of the WHI, one of the longest and most comprehensive studies ever done on postmenopausal women.

Jean Wactawski-Wende, PhD, principal investigator of UB’s Women’s Health Initiative (WHI) Center, discusses the significance of the WHI, one of the longest and most comprehensive studies ever done on postmenopausal women.