Amy E. Millen
PhD
Research Interests
Nutritional epidemiology and age-related chronic disease; age-related eye disease; periodontal disease; vitamin D; diet patterns; oral and gut microbiome
Selected Publications
- Millen AE, Nie J, Wactawski-Wende J, Andrews CA, Shadyab AH, Wallace RB, Patel SP. Fuchs Endothelial Corneal Dystrophy: A Post Hoc Analysis of the Women's Health Initiative Randomized Hormone Therapy Clinical Trials. JAMA Ophthalmol 2026 Feb 19:e256340.
- Burns KF, Blair RH, LaMonte MJ, Wactawski-Wende J, Rexrode KM, Balasubramanian R, Tabung FK, Snetselaar L, Millen AE. Metabolomic profiles of an atherogenic TMAO-dietary pattern among postmenopausal women. Eur J Nutr 2025; 64(6): 271.
- Burns KF, Mares J, Domalpally A, Hageman Blair R, LaMonte MJ, Wactawski-Wende J, Liu Z, Lawler T, Korger J, Millen AE. Dietary intake and an atherogenic dietary pattern in relation to retinal vessel caliber 15-years later in the carotenoids in age-related eye disease study. Clin Nutr 2025; 52: 275-83.
- Yue Y, Hovey KM, Wactawski-Wende J, LaMonte MJ, Andrews CA, Diaz PI, McSkimming DI, Buck M, Sun Y, Millen AE. Association Between Healthy Eating Index-2020 and Oral Microbiome Among Postmenopausal Women. J Nutr 2025; 155(1): 66-77.
- Gaber M, Wilson AS, Millen AE, Hovey KM, LaMonte MJ, Wactawski-Wende J, Ochs-Balcom HM, Cook KL. Visceral adiposity in postmenopausal women is associated with a pro-inflammatory gut microbiome and immunogenic metabolic endotoxemia. Microbiome 2024; 12(1): 192.
- Millen AE, Dighe S, Kordas K, Aminigo BZ, Zafron ML, Mu L. Air Pollution and Chronic Eye Disease in Adults: A Scoping Review. Ophthalmic Epidemiol. 2023 Mar 2:1-10. doi: 10.1080/09286586.2023.2183513. Online ahead of print. PMID: 36864662 Review.
- Millen AE, Dahhan R, Freudenheim JL, Hovey KM, Li L, McSkimming DI, Andrews CA, Buck MJ, LaMonte MJ, Kirkwood KL, Sun Y, Murugaiyan V, Tsompana M, Wactawski-Wende J. Dietary carbohydrate intake is associated with the subgingival plaque oral microbiome abundance and diversity in a cohort of postmenopausal women. Sci Rep. 2022 Feb 16;12(1):2643. doi: 10.1038/s41598-022-06421-2.
- Dighe S, Zhao J, Steffen L, Mares JA, Meuer SM, Klein BEK, Klein R, Millen AE. Diet patterns and the incidence of age-related macular degeneration in the Atherosclerosis Risk in Communities (ARIC) study. Br J Ophthalmol. 2020 Aug;104(8):1070-1076. doi: 10.1136/bjophthalmol-2019-314813. Epub 2019 Dec 6. PMID: 31810976
- Millen AE, Nie J, Sahli MW, Mares JA, Lutsey PL, LaMonte MJ, Meuers S, Andrews CA, , Klein BEK, Klein R. 25-Hydroxyvitamin D Concentrations and Incidence or Progression of Age-Related Macular Degeneration: the Atherosclerosis Risk in Communities Study (ARIC). Invest Ophthalmol Vis Sci. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1362-1371. doi: 10.1167/iovs.18-25945.
- Millen AE, Meyers KJ, Liu Z, Engelman CD, Wallace RB, LeBlanc ES, Tinker LF, Iyengar SK, Robinson JG, Sarto GE, Mares JA. Association Between Vitamin D Status and Age-Related Macular Degeneration by Genetic Risk. JAMA Ophthalmol. 2015 Oct 1;133(10):1171-9. doi: 10.1001/jamaophthalmol.2015.2715. PMID: 26312598.
- Millen AE, Andrews CA, LaMonte MJ, Hovey KM, Swanson M, Genco RJ, Wactawski-Wende J. Vitamin D status and 5-year changes in periodontal disease measures among postmenopausal women: the Buffalo OsteoPerio Study. J Periodontol. 2014 Oct;85(10):1321-32. Epub 2014 May 2. PMID: 24794688.
- Millen AE, Wactawski-Wende J, Pettinger M, Melamed ML, Tylavsky FA, Liu S, Robbins J, LaCroix AZ, LeBoff MS, Jackson RD. Predictors of serum 25-hydroxyvitamin D concentrations among postmenopausal women: the Women's Health Initiative Calcium plus Vitamin D clinical trial. Am J Clin Nutr. 2010May;91(5):1324-35. Epub 2010 Mar 10. PMID: 20219959.
- Millen AE, Bodnar LM. Vitamin D assessment in population-based studies: a review of the issues. Am J Clin Nutr. 2008 Apr;87(4):1102S-5S. Review. PMID: 18400742.
- Millen AE, Subar AF, Graubard BI, Peters U, Hayes RB, Weissfeld JL, Yokochi LA, Ziegler RG; PLCO Cancer Screening Trial Project Team. Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trial. Am J Clin Nutr. 2007 Dec;86(6):1754-64. PMID: 18065596.
- Millen AE, Gruber M, Klein R, Klein BE, Palta M, Mares JA. Relations of serum ascorbic acid and alpha-tocopherol to diabetic retinopathy in the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 2003 Aug 1;158(3):225-33. PMID: 12882944.