Endogenous Hormones and Premenopausal Breast Cancer Risk

Title: Endogenous Hormones and Premenopausal Breast Cancer Risk

Principal Investigator: Paola Muti, MD, MS

Funding Agency: NIH/NCI

Period: 07/01/04 - 06/30/07 (grant transferred to the Italian National Cancer Institute 6/06)

Abstract: Paola Muti left the department 2/05, went to the Italian National Cancer Institute and transferred the grant there.

This project evaluates the association of breast cancer with the endogenous steroid hormones (estradiol, testosterone and progesterone) and with IGF-I and insulin in premenopausal women using data from the Italian ORDET prospective cohort study. This project also evaluates whether the association of androgens and estrogens is explained, at least in part, by an underlying hyperinsulinemia-increased IGF-I bioavailability status. This study will provide important data on risk factors that are likely key to the development of premenopausal breast cancer.