John X. Wilson

PhD

John X. Wilson.

John X. Wilson

PhD

John X. Wilson

PhD

Professor Emeritus
Department of Exercise and Nutrition Sciences
School of Public Health and Health Professions

Research Topics

Responses to nutrients and drugs in inflammation and sepsis.

Overview Publications

Selected Publications

  • Li W, Ma Y, Li Z, Lv X, Wang X, Zhou D, Luo S, Wilson JX, Huang G. Folic acid decreases astrocyte apoptosis by preventing oxidative stress-induced telomere attrition. Int J Mol Sci. 2019;21:E62.
  • Lv X, Wang X, Wang Y, Zhou D, Li W, Wilson JX, Chang H, Huang G. Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism. Aging (Albany NY). 2019;11:10356-73.
  • Wang X, Li W, Li Z, Ma Y, Yan J, Wilson JX, Huang G. Maternal folic acid supplementation during pregnancy promotes neurogenesis and synaptogenesis in neonatal rat offspring. Cereb Cortex. 2018;29:3390–7.
  • Li W, Li Z, Li S, Wang X, Wilson JX, Huang G. Periconceptional folic acid supplementation benefit to development of early sensory-motor function through increased DNA methylation in offspring. Nutrients. 2018 Mar 1;10(3). pii:E292. doi: 10.3390/nu10030292.
  • Wang X, Li W, Li S, Yan J, Wilson JX, Huang G. Maternal folic acid supplementation during pregnancy improves neurobehavioral development in rat offspring. Mol Neurobiol. 2018;55:2676-84.
  • Li W, Liu H, Yu M, Zhang X, Zhang Y, Liu H, Wilson JX, Huang G. Folic acid alters methylation profile of JAK-STAT and long-term depression signaling pathways in Alzheimer's Disease models. Mol Neurobiol. 2016;53:6548-56.
  • Li W, Jiang M, Zhao S, Liu H, Zhang X, Wilson JX, Huang G. Folic Acid inhibits amyloid b-peptide production through modulating DNA methyltransferase activity in N2a-APP cells. Int J Mol Sci. 2015;16:25002-13.
  • Liu H, Li W, Zhao S, Zhang X, Zhang M, Xiao Y, Wilson JX, Huang G. Folic acid attenuates the effects of amyloid b oligomers on DNA methylation in neuronal cells. Eur J Nutr. 2016;55:1849-62.
  • Li W, Liu H, Yu M, Zhang X, Zhang M, Wilson JX, Huang G. Folic acid administration inhibits amyloid b-peptide accumulation in APP/PS1 transgenic mice. J Nutr Biochem. 2015;26:883-91.
  • Swarbreck S, Secor D, Ellis CG, Sharpe MD, Wilson JX, Tyml K. Effect of ascorbate on plasminogen activator inhibitor 1 expression and release from platelets and endothelial cells in an in-vitro model of sepsis. Blood Coagulation & Fibrinolysis. 2015;26:436-42.
  • Wilson JX. Antioxidants in sepsis. In: "Systems Biology of Free Radicals and Antioxidants". Ed., I. Laher. Springer-Verlag, Berlin, Heidelberg, pages 3267-3280, 2014.
  • Swarbreck S, Secor D, Li F, Gross PL, Ellis CG, Sharpe MD, Wilson JX, Tyml K. Effect of ascorbate on fibrinolytic factors in septic mouse skeletal muscle. Blood Coagul Fibrinolysis. 2014;25:745-53.
  • Swarbreck SB, Secor D, Ellis CG, Sharpe MD, Wilson JX, Tyml K. Short-term effect of ascorbate on bacterial content, plasminogen activator inhibitor-1, and myeloperoxidase in septic mice. J Surg Res. 2014;191:432-40.
  • Yu M, Li W, Luo S, Zhang Y, Liu H, Gao Y, Wang X, Wilson JX, Huang G. Folic acid stimulation of neural stem cell proliferation is associated with altered methylation profile of PI3K/Akt/CREB. J Nutr Biochem. 25:496-502, 2014.
  • Liu H, Cao J, Zhang H, Qin S, Yu M, Zhang X, Wang X, Gao Y, Wilson JX, Huang G. Folic acid stimulates proliferation of transplanted neural stem cells after focal cerebral ischemia in rats. J Nutr Biochem. 24:1817-22, 2013.
  • Wilson JX. Evaluation of vitamin C for adjuvant sepsis therapy. Antioxid Redox Signal. 19:2129-40, 2013.
  • Li W, Yu M, Luo S, Liu H, Gao Y, Wilson JX, Huang G. DNA methyltransferase mediates dose-dependent stimulation of neural stem cell proliferation by folate. J Nutr Biochem. 24:1295-1301, 2013.
  • Luo S, Zhang X, Yu M, Yan H, Liu H, Wilson JX, Huang G. Folic acid acts through DNA methyltransferases to induce the differentiation of neural stem cells into neurons. Cell Biochem Biophys. 66:559-66, 2013.
  • Yan H, Zhang X, Luo S, Liu H, Wang X, Gao Y, Wilson JX, Huang G. Effects of homocysteine on ERK signaling and cell proliferation in fetal neural stem cells in vitro. Cell Biochem Biophys. 66:131-7, 2013.
  • Andriantsitohaina R, Duluc L, Garcia-Rodriguez JC, Gil-del Valle L, Guevara-Garcia M, Simard G, Soleti R, Su DF, Velasquez-Perez L, Wilson JX, Laher I. Systems biology of antioxidants. Clin Sci (Lond). 123:173-92, 2012.
  • Zhang X, Huang G, Liu H, Chang H, Wilson JX. Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia. Nutr. Neurosci. 15:55-61, 2012.
  • Wilson JX, Wu F. Vitamin C in sepsis. Subcell. Biochem. 56:67-83, 2012.
  • Zhou G, Kamenos G, Pendem S, Wilson JX, Wu F. Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 302:R409-16, 2012.
  • Liu H, Huang G, Zhang X, Ren D, Wilson JX. Folic acid supplementation stimulates Notch signaling and cell proliferation in embryonic neural stem cells. J. Clin. Biochem. Nutr. 47:174-80, 2010.
  • Secor D, Li F, Ellis CG, Sharpe MD, Gross PL, Wilson JX, Tyml K. Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin mediated platelet adhesion in capillaries. Intensive Care Med. 36:1928-34, 2010.
  • Han M, Pendem S, Teh SL, Sukumaran DK, Wu F, Wilson JX. Ascorbate protects endothelial barrier function during septic insult: Role of protein phosphatase type 2A. Free Radical Biol. Med. 48:128-135, 2010.
  • Zhang XM, Huang GW, Tian ZH, Ren DL, Wilson JX. Folate stimulates ERK1/2 phosphorylation and cell proliferation in fetal neural stem cells. Nutr. Neurosci. 12:226-232, 2009.
  • Huang G, Cao X, Zhang X, Chang H, Yang Y, Du W, Wilson JX. Effects of soybean isoflavone on the Notch signal pathway of brain in rats with cerebral ischemia. J. Nutr. Sci. Vitaminol., 55:326-331, 2009.
  • Wu F, Han M, Wilson JX. Tripterine prevents endothelial barrier dysfunction by inhibiting endogenous peroxynitrite formation. Brit. J. Pharmacol. 157:1014-1023, 2009.
  • Pace P, Yao LJ, Wilson JX, Possmayer F, Veldhuizen RAW, Lewis JF. The effects of hyperoxia exposure on lung function and pulmonary surfactant in a rat model of acute lung injury. Exp. Lung Res. 35:380-398, 2009.
  • Wilson JX. Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium. BioFactors 35:5-13, 2009.
  • Wu F, Wilson JX. Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction. Cardiovasc. Res. 81:38-45,2009.
  • Zhang X, Liu H, Cong G, Tian Z, Ren D, Wilson JX, Huang G. Effects of folate on Notch signaling and cell proliferation in neural stem cells of neonatal rats in vitro. J. Nutr. Sci. Vitaminol. 54:353-356, 2008.
  • Huang G, Liu Y, Chang H, Zhang X, Ren D, Wilson JX, Cao X. Effects of genistein on oxidative injury in endothelial cells. J. Nutr. Sci. Vitaminol. 54:402-408, 2008.
  • Chan TS, Wilson JX, Selliah S, Bilodeau M, Zwingmann C, Poon R, O'Brien PJ. Organochlorines inhibit acetaminophen glucuronidation by redirecting UDP-glucuronic acid towards the D-glucuronate pathway. Toxicol. Appl. Pharmacol. 232:456-462, 2008.
  • Wu F, Tyml K, Wilson JX. iNOS expression requires NADPH oxidase-dependent redox signaling in microvascular endothelial cells. J. Cell. Physiol. 217:207-214, 2008
  • Ip J, Wilson JX, Uetrecht JP. Testing the hypothesis that vitamin C deficiency is a risk factor for clozapine-induced agranulocytosis using guinea pigs and ODS rats. Chem. Res. Toxicol. 21:869-873, 2008.
  • Tyml K, Li F, Wilson JX. Septic impairment of capillary blood flow requires NADPH oxidase but not NOS and is rapidly reversed by ascorbate through an eNOS-dependent mechanism. Crit. Care Med. 36:2355-2362, 2008.
  • Cepinskas G, Wilson JX. Inflammatory response in microvascular endothelium in sepsis: role of oxidants. J. Clin. Biochem. Nutr. 42: 175-184, 2008.