The University at Buffalo proposes a new Doctor of Philosophy (PhD) degree program in Computational Data Science and Engineering (CDSE) to train scientists and engineers to lead in these disciplines. Over the last few years – the human genome has been mapped; hurricanes and tornadoes are being predicted with greater accuracy; complex simulations are being used to design and test cars, planes and space vehicles before fabrication; crowds with thousands of people are kept safe by active monitoring for bad actors; online merchants such as Netflix and Amazon suggest to us the goods and services that meet our specific needs and wants – all of these innovations are made possible by revolutions in science and engineering driven by the use of large data and computation.