Personal factors, product characteristics, and changes in biomarkers of exposure among cigarette smokers who switch to noncombustible tobacco products

Researchers will examine factors associated with transitioning from cigarettes to noncombustible tobacco products, like smokeless tobacco and electronic cigarettes. 

Three rolled cigarettes.


The goal of this study is to evaluate the factors associated with transitioning from cigarettes to noncombustible tobacco products (e.g., smokeless tobacco, e-cigarettes) and assess the potential of noncombustibles as a harm reduction strategy. Researchers will evaluate four possible trajectories -- continued smoking (least optimal outcome), complete cessation (most optimal outcome), exclusive noncombustible use (possible harm reduction) or dual/poly tobacco use (unlikely harm reduction) -- through an analysis of Population Assessment of Tobacco and Health Study data. Study aims are: (1) to identify personal characteristics (e.g., sociodemographic characteristics, smoking history, harm perceptions, exposure to messaging/promotions) associated with switching from cigarettes to noncombustibles; (2) to describe product characteristics (e.g., cigarette characteristics, noncombustible characteristics such as flavor and nicotine content) associated with switching; and (3) to examine health outcomes and exposure biomarkers in smokers who have switched. Findings will provide new information related to switching from cigarettes to noncombustible tobacco products as a potential tobacco harm reduction strategy. 

Research Study Details

Principal Investigator

Research Team

Roswell Park Comprehensive Cancer Center

  • Kristopher Atwood, PhD
  • Karin Kasza, PhD
  • Richard O'Connor, PhD

Funding Agency

National Cancer Institute and FDA Center for Tobacco Products