Inheritable Epigenetic Biomarkers, Actions of Arsenic Exposure and Carcinogenic Activity

Title: Buffalo Clinical and Translational Research Center award for project "CTSA Pilot: Inheritable Epigenetic (DNA Methylation) Biomarkers and Actions of Arsenic Exposure in its Carcinogenic Activity"

Principal Investigator: Xuefeng Ren, MD, PhD

Funding Agency: National Center for Advancing Translational Sciences (NCATS)

Period: 05/17/15 - 03/31/17

Abstract: This study will determine whether arsenic exposure induces arsenic-specific inheritable DNA methylation changes, and to identify inheritable DNA methylation biomarkers that are transmitted from early generation and associated with arsenic-induced carcinogenesis.