Physiological Mechanisms of a Biomarker of Recovery from Concussion

lower body negative pressure.

This study will determine if exercise intolerance in concussion patients is due to low cardiac output or changes in skeletal muscle metabolism.

Principal Investigator: John J. Leddy, MD

Co-PI: Blair Johnson, PhD

Funding Agency: National Institutes of Health

Abstract: We have shown that concussion patients have exercise intolerance. The goal of this project is to determine if exercise intolerance in concussion patients is due to low cardiac output or changes in skeletal muscle metabolism.