Potential of Inhibition of Poly ADP Ribose Polymerase as a Therapeutic Approach in Blast Induced Cochlear and Brain Injury

Zoom image: Flowchart illustrating the various stages of using chemicals to inhibit PARP1, which increases anti-oxidant levels in cells, possibly due to the increased production of GCLC and GSH enzymes. This graphical abstract flowchart illustrates the various stages of using chemicals to inhibit PARP1, which increases anti-oxidant levels in cells, possibly due to the increased production of GCLC and GSH enzymes.

Flowchart illustrating the various stages of using chemicals to inhibit PARP1, which increases anti-oxidant levels in cells, possibly due to the increased production of GCLC and GSH enzymes.

Principal Investigator: Vijaya Prakash Krishnan Muthaiah, PT, PhD

Sponsor: Hearing Health Foundation

Awarded: July 2019

Description: To determine the mechanisms underlying both the peripheral and central aspects of blast-induced auditory neurodegeneration; and to identify and characterize potential pf PARP inhibition as a therapeutic targets for manifestations of blast-induced traumatic brain injury, including hearing loss, cochlear synaptopathy, tinnitus, and associated deficits.

When DNA is damaged by stress, cells activate Poly ADP Ribose Polymerase 1 (PARP1) as part of the repair process. Partially inhibiting PARP1 using chemicals has beneficial effects including increasing anti-oxidant levels in the cells. This study aims to understand how inhibiting PARP1 can help in the treatment of blast-induced traumatic hearing loss and tinnitus.